Alendronate prevents early joint degeneration following ACL injury

Our recent paper, Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice, published in Arthritis Research & Therapy, investigates the effect of a current osteoporosis treatment, alendronate, on joint health following injury. Alendronate is already understood to prevent bone loss, but has also been considered a contender for the treatment of osteoarthritis due to its potentially protective effects on cartilage. We used our novel, non-invasive mouse model of knee osteoarthritis to evaluate how two different alendronate regimens (low- and high-dose) influenced joint health after ACL rupture. We found that a high-dose of alendronate was able to prevent early bone loss and cartilage degeneration following injury, but that long-term joint degenerative effects were unmitigated. These results contribute to the knowledge surrounding alendronate and joint health, and may support the use of alendronate and other similar drugs following joint injury.

For more details, check out our paper in Arthritis Research & Therapy!

Khorasani et al. Arthritis Research & Therapy (2015) 17:30. DOI: 10.1186/s13075-015-0546-0

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