Congratulations to Hailey for passing her Qualifying Exam and becoming a PhD Candidate! We celebrated with beer and pizza at Village Pizza and Grill, but forgot to take pictures (as usual). Great job Hailey!
The 2017 UC Davis Biomedical Engineering Graduate Group (BMEGG) Student Research Conference was a great success once again! The conference opened with a talk from keynote speaker, Dr. Claudia Fischbach-Teschl of Cornell University, and had two speaker sessions and two poster sessions. Presentations were diverse, ranging from cardiovascular imaging techniques to the neuroscience of learning. Allison and Armaun presented two posters on osteophyte formation during post-traumatic osteoarthritis and systemic bone loss after fracture, respectively. At the end of the conference, the best oral presentation, best poster presentation, and the people’s choice award were presented certificates.
Congratulations to Armaun for winning Best Poster Presentation!
The Christiansen Lab has 3 posters and 1 podium presentation for ORS 2017 in San Diego, CA!
Stephanie Telek: Loss of Bone Stiffness at a Distant Skeletal Site Following Femoral Fracture in Mice
Armaun Emami: Age-Dependent Systemic Bone Loss and Recovery Following Femoral Fracture in Mice
Allison Hsia: Osteophyte Formation and the Effect of Mechanical Loading: Comparisons to Fracture Healing in Mice
Franklin Tarke: Comparison of Knee Injury Threshold During Tibial Compression Based on Limb Orientation in Mice
Congratulations Stephanie, Armaun, Allison, and Franklin!
Our work with the Loots Lab at Lawrence Livermore National Labs has been featured on News-Medical.net! The study is titled, “Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells,” and will be published in Bone in July 2016.
Read the News-Medical.net report here: http://www.news-medical.net/news/20160602/Sostdc1-gene-may-play-vital-role-in-fracture-healing-process.aspx
Our work with the Loots Lab at Lawrence Livermore National Lab has been featured on ScienceDaily.com. The study, titled “Global molecular changes in a tibial compression induced ACL rupture model of post‐traumatic osteoarthritis,” was published in the Journal of Orthopaedic Research in April 2016.
Be sure to check out the Science Daily article!
Our recent study, Osteophyte Formation After ACL Rupture in Mice is Associated With Joint Restabilization and Loss of Range of Motion, published in the Journal of Orthopaedic Research examined osteophyte development throughout the full time course of osteoarthritis (OA) and its effect on joint function. We used our noninvasive ACL rupture mouse model of post-traumatic OA (PTOA) to investigate how osteophyte formation correlated with changes in joint stability, characterized by anterior-posterior joint laxity, and range of motion (ROM). Stability and ROM both increased immediately after ACL rupture, but began decreasing only 2 weeks post-injury. Stability was restored to control levels after 8 weeks of injury, but ROM in injured limbs was significantly less than that of uninjured knees. These changes in joint function correlated well with osteophyte growth, but only if early chondrophyte development was also taken into consideration. This study suggests that while osteophytes do play a role in joint stabilization during PTOA, chondrophyte formation must be taken into consideration. Few studies currently examine chondrophyte formation, and these findings emphasize the importance of increasing our understanding of chondrophytes in osteophyte formation and OA progression.
Be sure to check out our study in the Journal of Orthopaedic Research!
Hsia et al. J Orthop Res (2016). DOI: 10.1002/jor.23252.